Friday, January 25, 2013

Most unknown species can be named

Most of the world's plant and animal species could be named before they go extinct, say researchers.

Writing in the journal Science, the researchers said it could be achieved this century.

This is largely a result of an increase in taxonomists - the people who describe species new to science.

The scientists acknowledge that although there is an extinction crisis, they say the rates are lower than previously thought.

Discovering and naming the world's species is critical for their conservation and can be done with only a modest increase in effort, the researchers stated.

But they also recognised it will be difficult to maintain a high rate of discovery as it becomes harder to find rare species.

Previous overestimates of the number of species - some as high as 100 million, led some in the scientific community to believe that it would be impossible to name all the world's species before they go extinct.

Naming a species gives formal recognition to its existence, making conservation easier, said lead author, Associate Professor Dr Mark Costello, from The University of Auckland.

"We believe that with just a modest increase in effort in taxonomy and conservation, most species could be discovered and protected from extinction."

As more information on taxonomy is available to the public via the internet, amateur as well as professional taxonomists are increasing, especially in regions such as Asia and South America, which are rich in biodiversity.

"We've discovered three times more people now naming species than there were ever before. We're in the golden age of taxonomy," added Dr Costello.

He hopes that this increase will continue, and that the public become more involved.

There are currently around around 1.5 million species which have been named. Dr Costello and his colleagues estimate the total number species on Earth ranges from two to eight million.

"Overestimates of the number of species on Earth are self-defeating because they can make attempts to discover and conserve biodiversity appear to be hopeless," said Dr Costello.

Jean-Christophe Vie, deputy director of the International Union for Conservation of Nature species programme, disagrees with the review's conclusion that "species are more likely to be described than become extinct".

"Extinction is usually underestimated. It's more important to fight extinction than to describe or catalogue all species," he said.

"We can protect species even if we don't know all of them. I have no doubt we can catalogue all of life, and it would be useful, but we don't have the luxury of time."

"I am worried by the message implying that to conserve species you need to know everything about them. You can do a lot of protection even in the absence of knowledge."

To reduce the time it takes to name the world's species, Dr Costello and colleagues recommend more taxonomists to be employed, increased financial support and international coordination in the scientific community to share expertise.

Professor Georgina Mace, from the Centre for Population Biology at Imperial College London, welcomes the analysis but also questions whether we really need to know the names of all species.

"Its excellent news, that taxonomic expertise is moving very effectively to tropical countries where most of the biodiversity on Earth is," she said.

She added that with sensible sampling, conservationists can prioritise effort on groups of species that are disappearing in the places most under threat.

"Once you've done that you can put in place conservation actions that will benefit everything there, whether named or not."

"It is part of our cultural responsibility to have looked at every single species on Earth, but because it can be difficult to do - particularly the last few percent - we need to be quite strategic about the effort put into discovering, describing, monitoring and conserving."

The levels of investment needed to name all the species is very modest, in global terms, said Professor Ken Norris, director of centre for Agri-Environmental research at Reading University.

He added that many species play important functional roles in the way Earth works and the life support systems they provide.

"If we lose them, important functions of those systems - like purifying water, providing fertile soils and clean air - might be damaged without us realising what we've lost," Prof Norris explained.

"Extinction isn't just about losing part of Earth's evolutionary history, it might also involve fundamental changes in the Earth's ecosystems that may have detrimental effects on mankind."

Source: http://www.bbc.co.uk/news/science-environment-21162197#sa-ns_mchannel=rss&ns_source=PublicRSS20-sa

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Right target, but missing the bulls-eye for Alzheimer's

Jan. 23, 2013 ? Alzheimer's disease is the most common cause of late-life dementia. The disorder is thought to be caused by a protein known as the amyloid-beta protein, or Abeta, which clumps together in the brain, forming plaques that are thought to destroy neurons. This destruction starts early, too, and can presage clinical signs of the disease by up to 20 years.

For decades now, researchers have been trying, with limited success, to develop drugs that prevent this clumping. Such drugs require a "target" -- a structure they can bind to, thereby preventing the toxic actions of Abeta.

Now, a new study out of UCLA suggests that while researchers may have the right target in Abeta, they may be missing the bull's-eye. Reporting in the Jan. 23 issue of the Journal of Molecular Biology, UCLA neurology professor David Teplow and colleagues focused on a particular segment of a toxic form of Abeta and discovered a unique hairpin-like structure that facilitates clumping.

"Every 68 seconds, someone in this country is diagnosed with Alzheimer's," said Teplow, the study's senior author and principal investigator of the NIH-sponsored Alzheimer's Disease Research Center at UCLA. "Alzheimer's disease is the only one of the top 10 causes of death in America that cannot be prevented, cured or even slowed down once it begins. Most of the drugs that have been developed have either failed or only provide modest improvement of the symptoms. So finding a better pathway for these potential therapeutics is critical."

The Abeta protein is composed of a sequence of amino acids, much like "a pearl necklace composed of 20 different combinations of different colors of pearl," Teplow said. One form of Abeta, Abeta40, has 40 amino acids, while a second form, Abeta42, has two extra amino acids at one end. Abeta42 has long been thought to be the toxic form of Abeta, but until now, no one has understood how the simple addition of two amino acids made it so much more toxic then Abeta40.

In his lab, Teplow and his colleagues used computer simulations in which they looked at the structure of the Abeta proteins in a virtual world. The researchers first created a virtual Abeta peptide that only contained the last 12 amino acids of the entire 42-amino-acid-long Abeta42 protein. Then, said Teplow, "we just let the molecule move around in a virtual world, letting the laws of physics determine how each atom of the peptide was attracted to or repulsed by other atoms."

By taking thousands of snapshots of the various molecular structures the peptides created, the researchers determined which structures formed more frequently than others. From those, they then physically created mutant Abeta peptides using chemical synthesis.

"We studied these mutant peptides and found that the structure that made Abeta42 Abeta42 was a hairpin-like turn at the very end of the peptide of the whole Abeta protein," Teplow said.

The hairpin turn structure was not previously known in the detail revealed by the researchers, "so we feel our experiments were novel," he said. "Our lab is the first to show that it is this specific turn that accounts for the special ability of Abeta42 to aggregate into clumps that we think kills neurons. Abeta40, the Abeta protein with two less amino acids at the end of the protein, did not do the same thing."

Hopefully, the work of the Teplow laboratory presents what may the most relevant target yet for the development of drugs to fight Alzheimer's disease, the researchers said.

Other authors on the study included Robin Roychaudhuri, Mingfeng Yang, Atul Deshpande, Gregory M. Cole and Sally Frautschy, all of UCLA, and Aleksey Lomakin and George B. Benedek of the Massachusetts Institute of Technology.

Funding for the study was provided by grants from the State of California Alzheimer's Disease Research Fund, a UCLA Faculty Research Grant, the National Institutes of Health (AG027818, NS038328) and the James Easton Consortium for Alzheimer's Drug Discovery and Biomarkers.

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The above story is reprinted from materials provided by University of California, Los Angeles (UCLA), Health Sciences.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Robin Roychaudhuri, Mingfeng Yang, Atul Deshpande, Gregory M. Cole, Sally Frautschy, Aleksey Lomakin, George B. Benedek, David B. Teplow. C-Terminal Turn Stability Determines Assembly Differences between A?40 and A?42. Journal of Molecular Biology, 2013; 425 (2): 292 DOI: 10.1016/j.jmb.2012.11.006

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/xGA4EgL4b6k/130123221409.htm

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Walmart Explores Offering Private Health Insurance for Small

Once again I am here to sing the praises of Walmart. Over the years I have done so on many occasions.

Many misguided souls take the other side. They blame Walmart for ruining mom and pop grocery stores, mom and pop hardware stores, etc.

Not me, I praise cheaper prices. Moreover, it's what consumers voted for with there hard-earned dollars.

If anyone wants to pay more for stuff, all they have to do is shop at a mom and pop hardware store, grocery store, or pharmacy. Most don't because they want a bargain.

Today, I have good news. Walmart-style competition may be on the way in the healthcare business.

The Orlando Business Journal writes Wal-Mart exploring private health insurance exchange for small biz.

Wal-Mart is exploring the idea of building a private health insurance exchange tailored to offer cheaper health insurance to small businesses, a vice president told Orlando Business Journal Jan. 11.

Marcus Osborne, vice president of health and wellness payer relations for Wal-Mart Stores Inc. (WMT), spoke to OBJ after his keynote speech at the Foundation of Associated Industries of Florida?s 2013 Health Care Affordability Summit. Osborne said Wal-Mart wants to work with insurers and managed care companies to find new, low-cost health insurance options tailored for small companies, which historically have limited options.

The idea is to offer those products through a health insurance exchange ? or as Osborne said, simply a marketplace ? that would leverage Wal-Mart?s buying and marketing power to make the exchanges widely available and used. ?It would allow small employers to piggyback Wal-Mart,? Osborne said. ?We haven?t got it all figured out, but it?s one of the things we?re looking at.?

?The biggest problem today small employers face from a health insurance perspective is they have no alternatives,? Osborne said. ?If they find anything, they?ve got to take it. There?s something wrong with that.?

In Praise of Walmart

Obamacare is going to raise the cost of healthcare. Walmart will lower costs. I have been waiting for this since Summer of 2008.

Flashback June 22, 2008: Trade Wars, Health Care, and Wal-Mart

This post is about trade wars, tariffs, health care, and Wal-Mart. I will tie these themes together starting with a look at Wal-Mart and health care.

I have many disagreements with Jim Jubak, but he hits the nail on the head with Let Wal-Mart fix US health care.

I know who can fix our broken health care system -- and who can't:
  • Not presumptive Republican nominee John McCain. He proposes a tax credit of $5,000 per family to encourage us to buy private health insurance.
  • Not Democratic presidential candidate Hillary Clinton. She proposes universal health insurance supported by tax credits.
  • Not Democratic presidential candidate Barack Obama. He proposes a mix of public and private health insurance with government subsidies to those who don't qualify for government insurance plans such as Medicaid.
I say, let Wal-Mart Stores (WMT) do it. Hold your guffaws. Stifle your impulse to scoff. Control those sputters of rage.

Wal-Mart has done more to expand coverage and lower costs in the past year than any government program to come out of Washington in the past 10 years. And I'd bet the new programs that this company -- known for stiffing its own part-time workers on health care benefits -- has announced in the past year will do more to expand coverage and cut costs than anything likely to come out of a McCain, Clinton or Obama first term.

Letting Wal-Mart run the health care system would fix many of those problems. It's a company that understands how low prices can build market share and thus increase profits. Furthermore, it's a company with a culture of cutting costs that has shown no compunction in pushing suppliers to the wall over price. The Wal-Mart motto ought to be, "Make it cheaper, or we'll find someone who can." I'd love to see that attitude brought to bear in health care.

Inquiring minds will want to read the rest of the article. It's surprisingly good.

Jubak makes a compelling case. He never said this explicitly but I will. "We do not need higher wages or higher prices. We need lower prices and a dollar that buys more".

Hopefully a good idea, long overdue, is about to happen. I repeat what I said in 2008: "We do not need higher wages or higher prices. We need lower prices and a dollar that buys more".

Walmart-style competition would do just that.

My primary fear is regulators will kill the idea based on trumped up charges of some sort (or bribes from healthcare providers who fear competition) before the idea takes hold.

Mike "Mish" Shedlock
http://globaleconomicanalysis.blogspot.com

Disclaimer:The content on this site is provided as general information only and should not be taken as investment advice. All site content, including advertisements, shall not be construed as a recommendation to buy or sell any security or financial instrument, or to participate in any particular trading or investment strategy. The ideas expressed on this site are solely the opinions of the author(s) and do not necessarily represent the opinions of sponsors or firms affiliated with the author(s). The author may or may not have a position in any company or advertiser referenced above. Any action that you take as a result of information, analysis, or advertisement on this site is ultimately your responsibility. Consult your investment adviser before making any investment decisions.

Source: http://globaleconomicanalysis.blogspot.com/2013/01/walmart-explores-offering-private.html

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Ryan blames Republican election loss on poor communication, turnout (reuters)

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Thursday, January 24, 2013

sometimes it's ?personal? - Thankfully the RAID is Gone

nilIt seems like the last few years ?have seen a plethora of lawsuits between major players against smaller competitors who have started to encroach upon their business. I have written about Symantec vs Veeam/Acronis in the past and I continue to have a keen interest in the use of patent infringement law and its deployment as a weapon against competitors. Let me preface the following by saying that a company has every right to litigate against another that infringes upon their intellectual property.?I do believe that there are legitimate cases to be made for infringement, but I also believe that the process in which overly broad patents are awarded is broken to the point that its harmful to innovation and a competitive and open playing field for businesses today.?Patent trolls continue to abuse the system and are a significant problem that has yet to be addressed fully.

But what really gets my goat:

Is selective patent enforcement. I believe that if anyone infringes on your licensed intellectual property and you bring suit, then you should not be only able to selectively enforce the patents against a select group. Meaning, if two companies are infringing on your technology you should have to sue both of them, not just the one you want to punish. ?Also, if let?s say Company A has a technology that they license to Company C, and it infringes on say Company B?s technology ?then Company A should be on the hook for legal costs associated with any suit. This tends to not be the case in many instances, especially in manufacturing where contacts will have liability limit clauses.

If it sounds convoluted and confusing, it kind of is. Legal fees for a basic defense can rack up quickly into the multi-millions, and in many cases the only group who comes out on top financially is the attorneys who get to reap hundreds of hours of fees as well as payments to legal experts who testify.? The perceived tendency is for both parties to reach agreement without going to trial, as it saves considerably on costs, but there are always those cases where one company will refuse to settle regardless of benefit, and are using the legal system to put a company out of business or punish them. Sometimes it?s not even due to any loss of business, it?s simply personal

Time for some rank speculation on my part:

Now as for EMC vs Zerto: reading through the initial filing, I think the case could be made for an infringement claim on its face, but I think it could also be ?personal?. I have friends who work at both companies, so it?s one of those delicate situations to discuss. Also, the problem with a simple filing is that it provides only one side of the story and so far I?ve not seen any legal response to the initial filing so its hard to see where both parties are coming from.

Sometimes you can read through the lines to get the general impression of whats at stake. The simple ?story revolves around 3 patents all stemming from Recovery Point Manager which is an EMC product that both of the primarily founders of Zerto worked on while at EMC. I think the key factor here is that EMC bought Kashya (where the Zerto Founders came to EMC) and in turn own certain technologies that EMC is stating that Zerto is infringing upon.

To me, a case like this should be pretty straight forward and will hinge on independent code review to see if the technology indeed infringes.? Still, I can?t help but think that Zerto?isn?t?cutting too much into EMC?s bottom line (I?d think more VMware and their SRM product), but given the history of the relationships between the parties involved, this may just be ?personal?.

I?d hazard a guess that the vast majority of people who read this had no idea that the two companies were engaged in legal processes, and I have not seen much if anything in the trade press regarding this suit. It was only brought to my attention via discussion on twitter. Technology is a tough business, stuff like this makes it tougher. I?m interested to see where this goes because I know a lot of people like the Zerto product, and they have gained significant?momentum?with their Best of VMworld 2011 win.?I will simply have to wait and see what comes next.

?

?

Source: http://gabrielchapman.com/?p=571

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Shakira Welcomes a Baby Boy! (For Real This Time)

The singer and beau Gerard Pique are new parents! Plus, see more stars who welcomed new bundles of joy

Source: http://www.ivillage.com/celebrity-babies-2011/1-b-16266?dst=iv%3AiVillage%3Acelebrity-babies-2011-16266

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Wednesday, January 23, 2013

Mrs. Obama has bangs: Let the analyzing begin

NEW YORK (AP) ? Before we start rambling on obsessively about Michelle Obama's bangs, let's be clear: The president started it.

It was he, after all, who called the new hairdo, unveiled just a few days before the historic occasion of his second inauguration, "the most significant event of this weekend."

And he hasn't stopped there. On Tuesday night, he introduced his wife at the Staff Inaugural Ball: "And the First Lady of the United States, bangs and all..."

So given the president's evident interest in the subject, perhaps the rest of us shouldn't feel so bad about analyzing ad nauseum the first lady's new look, an activity that has certainly taken over social media for days (and, perhaps, ended discussion of an earlier obsession, Michelle Obama's arms.) Heck, the bangs even have their own (unauthorized) Twitter account, FirstLady'sBangs, which has taken to issuing dispatches like: "Just got a text from Hillary Clinton's side-part" or "BREAKING NEWS: Barack just named me director of Hairline Security."

And how about the headline in New York's Daily News, the day after Obama's private swearing-in? "In With A Bang."

Quips and clever headlines aside, everyone seems to have an opinion about the new style ? not only how it looks, but what it means. And so, just because it's fun, we analyze some of them here:

THE YOUTH FACTOR: It's no secret, say fashion experts, that on the right person, bangs can make you look younger. It's also no secret that Mrs. Obama turned 49 the very day she unveiled the cut last week, in a photo tweeted from her new Twitter account, FLOTUS.

"None of this is accidental," says Linda Wells, Allure magazine's editor-in-chief. "She tried this on her 49th birthday. She wants to spice it up a bit. And it's definitely a more youthful style than what she had before. It just has a flirty, young quality to it."

THE FASHION PLATE: Clearly Mrs. Obama, well known and admired for her fashion sense, is aware that bangs are in these days. Sure, they've been around forever, and your 5-year-old may have them, but recently bangs have become a full-fledged fashion trend, with actress Zooey Deschanel one of the standard-bearers. (Fun fact: Deschanel, 33, and Mrs. Obama happen to share the same birthday ? Jan. 17.)

"Bangs have always been there, but they are clearly having a moment right now," says celebrity hairstylist Harry Josh, who was in Washington to style singer Kelly Clarkson's hair for the inauguration (Clarkson sang "My Country, 'Tis of Thee.") "Mrs. Obama is really being modern and fashion-forward. We haven't had a fashion-forward first lady like this since Jackie Kennedy."

New York hairstylist Robert Stuart agrees. "Bangs have been really, really big for about a year," he says. He thinks Mrs. Obama has picked the perfect cut for her looks. "It's much softer and younger, and it makes her look more approachable," Stuart says. "It also works well for her sense of fashion. And it brings out her eyes."

THE NAYSAYERS: Just in case one thinks everyone loves the hairdo ? and the reaction does seem extremely positive ? there are naysayers. Count among them Joan Rivers, comedienne and fashion commentator, who tweeted on Inauguration Day: "Today starts President Obama's next four years in the White House. Let's hope the same isn't true about the first lady's new hairdo." Explanation? She didn't provide one, but in her defense, she only had 140 characters.

SHE'S EXPRESSING HER INNER SELF: Here we get a little more philosophical. Some have speculated that, since Mrs. Obama is starting a second term and won't have to endure any more campaigns, she's finally free to express herself exactly as she wants ? and feels. "Haircuts do express how people are feeling," says Wells. "You get that sense of her feeling liberated ? more comfortable, and less worried about what everyone else is thinking. She's showing her own sense of style and own sense of energy."

Stuart, of the Robert Stuart Salon, has a similar thought. "I think now she's maybe feeling less threatened, and can express herself more. Really she just seems more comfortable."

IT'S SOMETHING TO EVERYONE: If you'd wandered around the National Mall on Inauguration Day, and spoke to women especially, you'd have found a lot of Michelle Obama fans. No surprise there. But many of these women were also fond of the bangs, and for various reasons.

Sheila Garrison, an educator from Maryland, called the hairstyle "different," but all the attention paid to it brought home to her and her friend, fellow teacher Patricia Cooper, that Mrs. Obama "represents women in a beautiful way," in Cooper's words. "You look at her and you are proud to be a woman. She commands respect." Garrison, 58, also appreciated how Mrs. Obama, a fellow tall woman, "carries herself really well."

Mattece Mason, 34, of Tulsa, Okla., adores the cut ? when asked about, it she and her family members ? well, the females ? screamed, "Oh my God, we love it!" But the enthusiasm of her daughters was meaningful to Mason for a reason other than fashion. "My daughter Aubrianna, who's 14, said to me today: 'I want bangs now,'" Mason said. "That made me feel great because my girls have such a role model. A first lady they can emulate." (Mason also mentioned she thought Secretary of State Hillary Rodham Clinton looked great in those eyeglasses she's been sporting lately.)

And Roslyn Snow, of Newport Beach, Calif., had another reason for loving the new Obama look. "I think she looks like Jane Fonda back in the old days," said Snow, 76. "Remember?"

A SIGN OF SOMETHING BIGGER?: Many have wondered whether Mrs. Obama has plans to forge a new role in the second term, taking on different issues. Wells, the fashion editor, gets that feeling, though she makes clear it's all speculation. "You sense it with the strong statement she is making with her appearance," Wells says. "Before, her look was sort of retrograde: the hair, the A-line dresses. The emphasis was on 'lady.' Now, it seems, the emphasis is on 'first lady.'"

A POLITICAL STATEMENT?: Josh, Clarkson's stylist, likes to see a broader message in the haircut choice. "Think about President Obama's statement in his speech about gay people as equals. It was so forward-looking. Mrs. Obama was saying something similar, I'd like to think. She was putting America into the position of a forward-thinking country."

Or not. "Of course," adds Josh, "she could just have been bored with her hair the old way."

Source: http://news.yahoo.com/mrs-obama-bangs-let-analyzing-begin-214622965--politics.html

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